Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata

A new withanolide glycoside from physalis peruviana

A new withanolide glycoside, 17beta-hydroxy-14, 20-epoxy-1-oxo-[22R]-3beta-[O-beta-D-glucopyranosyl]-witha-5, 24-dienolide (1), has been isolated from the whole plant of Physalis peruviana. Its identity was determined using a combination of spectroscopic data including 2D NMR techniques and chemical transformations.

Cytotoxic withanolide constituents of Physalis longifolia.

Fourteen new withanolides, 1-14, named withalongolides A-N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15-22). The structures of compounds 1-14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using...

A novel withanolide with an unprecedented carbon skeleton from Physalis angulata.

A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)-C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 μM. A ...

Cytotoxic withanolides from Vietnamese ethno-medicinal plant Physalis angulata

Withanolides are known as the main components of Physalis genus with broad biological activities. Using combination of various chromatographic methods, three withanolides were isolated including physagulin J (1), physagulin K (2), and physagulin N (3). Their chemical structures were determined by analysis of NMR spectra, and as well as comparison with reported literature. Compound 1 showed sign...

Physalis Angulata L . : an Ethanopharmacological Review